Fri May 27 2022

39 articles - From Friday May 20 2022 to Friday May 27 2022

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Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews


Original articles

RCT, clinical trials, retrospective studies, etc…

Ann Rheum Dis

Biological insights into systemic lupus erythematosus through an immune cell-specific transcriptome-wide association study.

We demonstrated in vitro that putative causal variant rs61759532 exhibited an allele-specific regulatory effect on ACAP1, and that presence of the SLE risk allele decreased ACAP1 expression. Cell-level TWAS in six types of immune cells complemented SLE gene discovery and guided the identification of novel genetic associations. The gene findings shed biological insights into SLE genetic associations.

Pubmed   Journal   ReadQx 

Induced antibodies directed to the angiotensin receptor type 1 provoke skin and lung inflammation, dermal fibrosis and act species overarching.

Our immunisation strategy successfully induced AT1R Abs, contributing to inflammation and, possibly, to fibrosis via activation of AT1R. Therefore, AT1R Abs are valuable targets for future therapies of SSc and other AT1R Ab-related diseases.

Pubmed   Journal   ReadQx 

Mechanism of action of baricitinib and identification of biomarkers and key immune pathways in patients with active systemic lupus erythematosus.

Inflammatory biomarkers indicated correlations/associations with type I IFN (CCL19, CXCL10, TNF-a and PD-L1), anti-double stranded DNA (dsDNA) (TNF-a, CXCL10) and Systemic Lupus Erythematosus Disease Activity Index-2000, tender and swollen joint count and worst joint pain (CCL19, IL-6 and TNFRSF9/CD137). These results suggest that baricitinib 4mg downregulated key cytokines that are upregulated in patients with SLE and may play a role in a multitargeted mechanism beyond the IFN signature although clinical relevance remains to be further delineated. NCT02708095.

Pubmed   Journal   ReadQx 

MRI lesions of the spine in patients with axial spondyloarthritis: an update of lesion definitions and validation by the ASAS MRI working group.

The most reliably assessed lesions were VC fat lesion and VC monomorphic BMO (ICC (mean of al 36 reader pairs/overall 9 readers): 0.91/0.92; 0.70/0.67, respectively. The lesion definitions for spinal MRI lesions compatible with SpA were updated by consensus and validated by a group of experienced readers. The lesions with the highest frequency and best reliability were fat and monomorphic inflammatory lesions at the VC.

Pubmed   Journal   ReadQx 

Risk of cardiovascular events in patients having had acute calcium pyrophosphate crystal arthritis.

Acute CPP crystal arthritis was significantly associated with increased risk for MACE in years 0-2 (HR 1.32, 95%CI 1.01 to 1.73) and non-fatal CV event in years 0-2 (HR 1.92, 95%CI 1.12 to 3.28) and years 2-10 (HR 2.18, 95%CI 1.27 to 3.75), but not death. Results of sensitivity analyses were similar to the primary analysis; in the outpatient-only analysis, risk of non-fatal CVE was significantly elevated in years 2-10 but not in years 0-2. Acute CPP crystal arthritis was significantly associated with elevated short and long-term risk for non-fatal CV event.

Pubmed   Journal   ReadQx 

Arthritis Care Res (Hoboken)

Bone marrow lesions and MRI-detected structural abnormalities in people with midfoot pain and osteoarthritis: a cross-sectional study.

In people with persistent midfoot pain but no x-ray signs of OA, MRI findings suggested an under-recognised prevalence of OA, particularly in the 2 nd and 3 rd cuneiform-metatarsal joints, where BML patterns were consistent with previously recognised sites of elevated mechanical loading. Joint abnormalities were not strongly associated with pain or foot-related disability.

Pubmed   Journal   ReadQx 

Factors influencing pain response following GLA:D® patient education and supervised exercise in males and females with hip osteoarthritis.

Findings suggest that the influence of some factors on pain response differ for males and females, and point to a potential need for targeted approaches for males and females who may require different key messages/approaches from healthcare providers.

Pubmed   Journal   ReadQx 

Identification of Multimorbidity Patterns in Rheumatoid Arthritis through Machine Learning.

Cardiopulmonary, cardiometabolic, and mental health and chronic pain disorders represent predominant multimorbidity patterns, each of which are over-represented in RA. The identification of multimorbidity patterns occurring more frequently in RA is an important first step in progressing toward a holistic approach to RA management and warrants assessment of their clinical and predictive utility.

Pubmed   Journal   ReadQx 

Lung Ultrasound in Children with Systemic Juvenile Idiopathic Arthritis Associated Interstitial Lung Disease.

LUS in sJIA-LD reveals highly conspicuous abnormalities in the pleura and sub-pleura that appear to correlate with peripheral lung findings on HRCT. LUS is a feasible imaging tool in children even from an early age. This study suggests a potential role of LUS in sJIA-LD screening, diagnosis, and/or prognostication.

Pubmed   Journal   ReadQx 

Remission and Low-Disease Activity in Granulomatosis with Polyangiitis and Microscopic Polyangiitis: Prevalence and Impact on Damage Accrual.

More than 60% of GPA/MPA achieved prolonged remission, which was associated with better long-term outcomes. In contrast, prolonged LDAS correlated with increased damage accrual and was not a sufficient treatment target.

Pubmed   Journal   ReadQx 

Risk of Prostate Cancer in U.S. Veterans with Rheumatoid Arthritis.

RA was associated with a modestly increased risk of prostate cancer, but not prostate cancer mortality, after accounting for relevant confounders and several potential sources of bias. However, even minimal unmeasured confounding could explain these findings.

Pubmed   Journal   ReadQx 

The impact of clinical association between gout and dementia: a nationwide population-based cohort study in Korea.

Gout decreased the risk of incident AD-type dementia, especially in elderly patients. The association between gout and dementia risk may differ according to age and disease duration.

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Arthritis Res Ther

Accuracy and tolerability of self-sampling of capillary blood for analysis of inflammation and autoantibodies in rheumatoid arthritis patients-results from a randomized controlled trial.

DRKS. de Identifier: DRKS00023526 . Registered on November 6, 2020.

Pubmed   Journal   ReadQx 

Circulating Th2 cell reduction and Th1/Th2 imbalance are correlated with primary Sjogren's syndrome-associated interstitial lung disease.

Decreased circulating Th2 cells and an elevated Th1/Th2 ratio may be the immunological mechanism underlying the development of ILD in pSS patients.

Pubmed   Journal   ReadQx 

Excessive mechanical stress-induced intervertebral disc degeneration is related to Piezo1 overexpression triggering the imbalance of autophagy/apoptosis in human nucleus pulpous.

Piezo1 upregulation under excessive mechanical stress promotes the apoptosis, senescence, and pro-inflammatory cytokines of NP and leads to the loss of extracellular matrix by mitochondrial dysfunction and the suppression of autophagy; on the other hand, the inhibition of Piezo1 can partly alleviate these effects.

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High risk of depression, anxiety, and an unfavorable complex comorbidity profile is associated with SLE: a nationwide patient-level study.

Our analysis indicates the enormity of comorbidity burden in SLE, especially that of anxiety and depression. The size and complexity of the comorbidity burden emphasizes the importance of early diagnosis and intervention with comprehensive modalities incorporating attention to comorbidities in SLE patients.

Pubmed   Journal   ReadQx   PMC

Identification of biomarkers by machine learning classifiers to assist diagnose rheumatoid arthritis-associated interstitial lung disease.

The levels of KL-6, D-dimer, and tumor markers greatly aided RA-ILD identification. Machine learning algorithms combined with traditional biostatistical analysis can diagnose patients with RA-ILD and identify biomarkers potentially associated with the disease.

Pubmed   Journal   ReadQx 

Mass spectrometry-based proteomics identify novel serum osteoarthritis biomarkers.

Our study suggests that 4 proteins, CRTAC1, FBN1, VDBP, and possibly SERPINF1, warrant further investigation as potential new biomarker candidates for the whole OA population.

Pubmed   Journal   ReadQx 

Monitoring of patients with rheumatoid arthritis by indocyanine green (ICG)-enhanced fluorescence optical imaging treated with anti-TNFa therapy.

FOI in P1 appears to be a valuable tool for fast and easy monitoring of treatment response to certolizumab in a clinical setting.

Pubmed   Journal   ReadQx 

The effects of custom-made foot orthoses on foot pain, foot function, gait function, and free-living walking activities in people with psoriatic arthritis (PsA): a pre-experimental trial.

ClinicalTrials. gov , NCT05075343 . Retrospectively registered on September 29, 2021.

Pubmed   Journal   ReadQx 

Arthritis Rheumatol

In vivo generating SSA/Ro-antigen specific regulatory T cells improves experimental Sjögren's syndrome in mice.

Our findings provide a new approach to generating antigen-specific Tregs in vivo for SS treatment, which should have implications for potential therapy for patients with SS.

Pubmed   Journal   ReadQx 

Patterns of arthritis flare reveal joint-specific memory together with sustained risk for new joint accumulation.

Arthritis flares preferentially affect previously inflamed joints but carry an ongoing risk of disease extension. These findings confirm joint-specific memory and suggest that prevention of new joint accumulation should be an important target for arthritis therapy.

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Symptom-Based Cluster Analysis Categorizes Sjögren's Disease Subtypes and Highlights the Discordance Between Disease Severity and Treatment: an International Cohort Study.

We identified four symptom-based Sjgren's clusters and showed that symptom burden and immunomodulatory use do not correlate with Sjgren's end-organ or laboratory abnormalities. Findings highlight a discordance between objective measures and treatments and offer updates to proposed symptom-based clustering approaches.

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Rheumatology (Oxford)

Is time a healer? How quality of life changes over time reported by parents of children and young people with Juvenile Idiopathic Arthritis.

Children and young people with JIA have low HRQoL across domains compared with the reference population. This improves within 3years of diagnosis, with the greatest improvement within the first year. Early, developmentally-appropriate clinical intervention is recommended to reduce both psychosocial and physical impact of JIA. The lower HRQoL scores of females requires further investigation.

Pubmed   Journal   ReadQx 

The SUMO components in rheumatoid arthritis.

In addition, single nucleotide polymorphisms (SNPs) in the SUMO components have been reported to be associated with disease susceptibility. Until now, only the SNP site of SUMO-4 has been reported in RA. Here we provided a systematic overview of the general characteristics of SUMO components and highlighted a summary of their impact on RA.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link


Letters&Replies

Letters to the editors and authors’ replies

Ann Rheum Dis

Correspondence on "Isolation of HLA-DR-naturally presented peptides identifies T-cell epitopes for rheumatoid arthritis" by Maggi et al.

Pubmed   Journal   ReadQx 

Arthritis Res Ther

Comment on "The risk of malignancy in patients with IgG4-related disease: a systematic review and meta-analysis" by Yu et al.

Third, the causation between IgG4-RD and malignancy remains obscure currently. The time course for development in different malignancies varies significantly so that we cannot infer that malignancies discovered after IgG4-RD are directly relevant. With problems mentioned above, we recommend solutions to make this article more convincing.

Pubmed   Journal   ReadQx 

Reply to the comment on "Accuracy and usability of a diagnostic decision support system in the diagnosis of three representative rheumatic diseases: a randomized controlled trial among medical students".

Pubmed   Journal   ReadQx 

Arthritis Rheumatol

Response to response letter: 'Criteria for the pathogenicity of anticentromere (anti-CENP-B) autoantibodies in systemic sclerosis: Comment on the article of van Leeuwen et al'.

Pubmed   Journal   ReadQx 


Others

all remaining publications eg case reports, images of the month, etc…

Ann Rheum Dis

Guselkumab for treating immune checkpoint inhibitor-induced psoriatic arthritis.

Pubmed   Journal   ReadQx 

Response to: Correspondence on "HLA-DR 'naturally' presented peptides: you will find what you have pulsed with" by Maggi et al.

Pubmed   Journal   ReadQx 

Arthritis Rheumatol

A rare Scleroderma mimic: Huriez Syndrome.

Pubmed   Journal   ReadQx 

Rheumatology (Oxford)

A case of recurrent IgG4-related disease successfully treated with belimumab after remission of systemic lupus erythematosus.

Pubmed   Journal   ReadQx 

An adult case of suspected A20 haploinsufficiency mimicking polyarteritis nodosa.

Pubmed   Journal   ReadQx 

Changes to expert opinion in the use of antirheumatic drugs before and during pregnancy five years after EULAR: points to consider.

Pubmed   Journal   ReadQx 

COVID-19 mRNA vaccine booster in patients with autoimmune rheumatic diseases.

Pubmed   Journal   ReadQx 

Immunological changes and prevention of disease progression through elotuzumab therapy in refractory IgG4-related sclerosing mesenteritis.

Pubmed   Journal   ReadQx 

Phalangeal involvement as an initial presentation in SAPHO syndrome.

Pubmed   Journal   ReadQx 

Successful remission with tofacitinib in a patient with refractory bullous systemic lupus erythematosus.

Pubmed   Journal   ReadQx