39 articles - From Friday May 20 2022 to Friday May 27 2022
Guidelines, position statements, white papers, technical reviews, consensus statements, etc…
meta-analyses and systematic reviews
RCT, clinical trials, retrospective studies, etc…
| Ann Rheum Dis |
Biological insights into systemic lupus erythematosus through an immune cell-specific transcriptome-wide association study. We demonstrated in vitro that putative causal variant rs61759532 exhibited an allele-specific regulatory effect on ACAP1, and that presence of the SLE risk allele decreased ACAP1 expression. Cell-level TWAS in six types of immune cells complemented SLE gene discovery and guided the identification of novel genetic associations. The gene findings shed biological insights into SLE genetic associations. |
Induced antibodies directed to the angiotensin receptor type 1 provoke skin and lung inflammation, dermal fibrosis and act species overarching. Our immunisation strategy successfully induced AT1R Abs, contributing to inflammation and, possibly, to fibrosis via activation of AT1R. Therefore, AT1R Abs are valuable targets for future therapies of SSc and other AT1R Ab-related diseases. |
Mechanism of action of baricitinib and identification of biomarkers and key immune pathways in patients with active systemic lupus erythematosus. Inflammatory biomarkers indicated correlations/associations with type I IFN (CCL19, CXCL10, TNF-a and PD-L1), anti-double stranded DNA (dsDNA) (TNF-a, CXCL10) and Systemic Lupus Erythematosus Disease Activity Index-2000, tender and swollen joint count and worst joint pain (CCL19, IL-6 and TNFRSF9/CD137). These results suggest that baricitinib 4 |
MRI lesions of the spine in patients with axial spondyloarthritis: an update of lesion definitions and validation by the ASAS MRI working group. The most reliably assessed lesions were VC fat lesion and VC monomorphic BMO (ICC (mean of al 36 reader pairs/overall 9 readers): 0.91/0.92; 0.70/0.67, respectively. The lesion definitions for spinal MRI lesions compatible with SpA were updated by consensus and validated by a group of experienced readers. The lesions with the highest frequency and best reliability were fat and monomorphic inflammatory lesions at the VC. |
Risk of cardiovascular events in patients having had acute calcium pyrophosphate crystal arthritis. Acute CPP crystal arthritis was significantly associated with increased risk for MACE in years 0-2 (HR 1.32, 95% |
| Arthritis Care Res (Hoboken) |
Bone marrow lesions and MRI-detected structural abnormalities in people with midfoot pain and osteoarthritis: a cross-sectional study. In people with persistent midfoot pain but no x-ray signs of OA, MRI findings suggested an under-recognised prevalence of OA, particularly in the 2 nd and 3 rd cuneiform-metatarsal joints, where BML patterns were consistent with previously recognised sites of elevated mechanical loading. Joint abnormalities were not strongly associated with pain or foot-related disability. |
Factors influencing pain response following GLA:D® patient education and supervised exercise in males and females with hip osteoarthritis. Findings suggest that the influence of some factors on pain response differ for males and females, and point to a potential need for targeted approaches for males and females who may require different key messages/approaches from healthcare providers. |
Identification of Multimorbidity Patterns in Rheumatoid Arthritis through Machine Learning. Cardiopulmonary, cardiometabolic, and mental health and chronic pain disorders represent predominant multimorbidity patterns, each of which are over-represented in RA. The identification of multimorbidity patterns occurring more frequently in RA is an important first step in progressing toward a holistic approach to RA management and warrants assessment of their clinical and predictive utility. |
Lung Ultrasound in Children with Systemic Juvenile Idiopathic Arthritis Associated Interstitial Lung Disease. LUS in sJIA-LD reveals highly conspicuous abnormalities in the pleura and sub-pleura that appear to correlate with peripheral lung findings on HRCT. LUS is a feasible imaging tool in children even from an early age. This study suggests a potential role of LUS in sJIA-LD screening, diagnosis, and/or prognostication. |
Remission and Low-Disease Activity in Granulomatosis with Polyangiitis and Microscopic Polyangiitis: Prevalence and Impact on Damage Accrual. More than 60% of GPA/MPA achieved prolonged remission, which was associated with better long-term outcomes. In contrast, prolonged LDAS correlated with increased damage accrual and was not a sufficient treatment target. |
Risk of Prostate Cancer in U.S. Veterans with Rheumatoid Arthritis. RA was associated with a modestly increased risk of prostate cancer, but not prostate cancer mortality, after accounting for relevant confounders and several potential sources of bias. However, even minimal unmeasured confounding could explain these findings. |
The impact of clinical association between gout and dementia: a nationwide population-based cohort study in Korea. Gout decreased the risk of incident AD-type dementia, especially in elderly patients. The association between gout and dementia risk may differ according to age and disease duration. |
| Arthritis Res Ther |
Circulating Th2 cell reduction and Th1/Th2 imbalance are correlated with primary Sjogren's syndrome-associated interstitial lung disease. Decreased circulating Th2 cells and an elevated Th1/Th2 ratio may be the immunological mechanism underlying the development of ILD in pSS patients. |
Excessive mechanical stress-induced intervertebral disc degeneration is related to Piezo1 overexpression triggering the imbalance of autophagy/apoptosis in human nucleus pulpous. Piezo1 upregulation under excessive mechanical stress promotes the apoptosis, senescence, and pro-inflammatory cytokines of NP and leads to the loss of extracellular matrix by mitochondrial dysfunction and the suppression of autophagy; on the other hand, the inhibition of Piezo1 can partly alleviate these effects. |
High risk of depression, anxiety, and an unfavorable complex comorbidity profile is associated with SLE: a nationwide patient-level study. Our analysis indicates the enormity of comorbidity burden in SLE, especially that of anxiety and depression. The size and complexity of the comorbidity burden emphasizes the importance of early diagnosis and intervention with comprehensive modalities incorporating attention to comorbidities in SLE patients. |
Identification of biomarkers by machine learning classifiers to assist diagnose rheumatoid arthritis-associated interstitial lung disease. The levels of KL-6, D-dimer, and tumor markers greatly aided RA-ILD identification. Machine learning algorithms combined with traditional biostatistical analysis can diagnose patients with RA-ILD and identify biomarkers potentially associated with the disease. |
| Arthritis Rheumatol |
In vivo generating SSA/Ro-antigen specific regulatory T cells improves experimental Sjögren's syndrome in mice. Our findings provide a new approach to generating antigen-specific Tregs in vivo for SS treatment, which should have implications for potential therapy for patients with SS. |
Patterns of arthritis flare reveal joint-specific memory together with sustained risk for new joint accumulation. Arthritis flares preferentially affect previously inflamed joints but carry an ongoing risk of disease extension. These findings confirm joint-specific memory and suggest that prevention of new joint accumulation should be an important target for arthritis therapy. |
Symptom-Based Cluster Analysis Categorizes Sjögren's Disease Subtypes and Highlights the Discordance Between Disease Severity and Treatment: an International Cohort Study. We identified four symptom-based Sj |
| Rheumatology (Oxford) |
Is time a healer? How quality of life changes over time reported by parents of children and young people with Juvenile Idiopathic Arthritis. Children and young people with JIA have low HRQoL across domains compared with the reference population. This improves within 3 |
The SUMO components in rheumatoid arthritis. In addition, single nucleotide polymorphisms (SNPs) in the SUMO components have been reported to be associated with disease susceptibility. Until now, only the SNP site of SUMO-4 has been reported in RA. Here we provided a systematic overview of the general characteristics of SUMO components and highlighted a summary of their impact on RA. |
Plenty of the editorials are available as full text through the publisher website using the provided link
Letters to the editors and authors’ replies
| Ann Rheum Dis |
| Arthritis Res Ther |
Comment on "The risk of malignancy in patients with IgG4-related disease: a systematic review and meta-analysis" by Yu et al. Third, the causation between IgG4-RD and malignancy remains obscure currently. The time course for development in different malignancies varies significantly so that we cannot infer that malignancies discovered after IgG4-RD are directly relevant. With problems mentioned above, we recommend solutions to make this article more convincing. |
| Arthritis Rheumatol |
all remaining publications eg case reports, images of the month, etc…
| Ann Rheum Dis |
| Arthritis Rheumatol |
| Rheumatology (Oxford) |